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Case-control breast cancer study of MALDI-TOF proteomic mass spectrometry data on serum samples.

van der Werff MP, Mertens B, de Noo ME, Bladergroen MR, Dalebout HC, Tollenaar RA, Deelder AM

Leiden University Medical Center. m.p.j.van der werff@lumc.nl

We introduce mass spectrometry proteomic research for diagnosis from a clinical perspective, with special reference to early-stage breast cancer detection. The nature of SELDI and MALDI mass spectrometric measurement is discussed. We explain how the mass spectral data arising from this technology may be viewed as a new data type. Some of the properties of the data are discussed and we show how such spectra may be interpreted. Sample preprocessing for mass spectrometry is introduced and a literature review of research in clinical proteomics is presented. Finally, we provide a detailed description of the study design on the breast cancer case-control study which is investigated in this special issue.

Published 4 February 2008 in Stat Appl Genet Mol Biol, 7: Article2.
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