Breast Cancer Research Today is a free monthly online journal that collates and summarizes the latest research about Breast Cancer, including details on symptoms, genetics, screening, treatment, information.

mAtNOS1 induces apoptosis of human mammary adenocarcinoma cells.

Parihar A, Parihar MS, Chen Z, Ghafourifar P

Department of Surgery, Heart and Lung Research Institute, and Institute of Mitochondrial Biology, The Ohio State University, Columbus, Ohio, USA.

mAtNOS1 is a novel gene recently reported in mammalian genome with functions that are not fully understood. The present study shows that in human mammary adenocarcinoma MCF-7 cells, mAtNOS1 expression increases mitochondrial nitric oxide and calcium. Our study further shows that overexpression of mAtNOS1 induces apoptosis in MCF-7 cells by increasing mitochondrial protein tyrosine nitration and cytochrome c release. The present study suggests a novel function for mAtNOS1 in regulating mitochondrial nitric oxide and calcium and inducing apoptosis of MCF-7 cells.

Published 12 May 2008 in Life Sci, 82(21): 1077-82.
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