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Overall survival in women with breast cancer: the influence of pepsinogen C gene polymorphism.

Pinto-Correia AL, Pinto D, Pereira D, Rodrigues H, de Sousa JA, Sousa H, Sousa B, Sousa S, Lopes C, Medeiros R

Molecular Oncology Group, Portuguese Institute of Oncology, Porto, Portugal.

We aimed to study the role of an insertion/deletion polymorphism in the Pepsinogen C (PGC) gene in the clinical outcome of 172 breast cancer patients. The six polymorphic alleles were amplified using PCR. Our results indicate that patients carrying the allele 6 present a higher 5-year survival mean (83.4% of 6 allele carriers were alive at 5 years vs. only 68.6% of noncarriers, p=0.001), suggesting a role for this polymorphism in the outcome of breast cancer patients. We hypothesize that PGC polymorphism can be a predictive biomarker in breast cancer, contributing to an individual profile of great interest in clinical oncology.

Published 13 June 2008 in DNA Cell Biol, 27(6): 333-6.
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